Product Description

Topinate 30 gm contains the active component clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Dermatologists prescribe it for the topical therapy of recalcitrant corticosteroid-responsive dermatoses, including severe cases of psoriasis and eczematous dermatitis. Clobetasol Propionate is the potent active ingredient present in the drug Topinate 30 gm. It is effective for the treatment of pruritic manifestations and helps in reducing inflammation. Like other topical corticosteroids, Clobetasol propionate has antipruritic, anti-inflammatory, and vasoconstrictive properties. The mode of action of the anti-inflammatory activity of this topical agent is still not understood. Treatment beyond two weeks is not recommended. The corticosteroid therapy should be discontinued when control has been achieved. If no improvement is seen within two weeks of regular usage, reassessment of the diagnosis may be necessary. It is the most widely used preparation and the most preferred combination recommended by experts. 

How To Use

Topinate 30 gm drug is available in cream, making it easier to apply on the affected portion. This topical formulation should be applied in an adequate amount depending on the medical condition. Initially, it should be applied twice a day, and later, the dose can be adjusted as per the response of the patient towards the drug under the supervision of your doctor. Report your doctor after a regular time interval of 3 to 4 weeks. Do not apply this lotion more than the required amount. If you get rashes and itchy skin, consult your doctor and do as instructed.

Precautions

Topinate 30 gm drug is reported to contraindicate in the following cases:

• Patients with a history of Clobetasol propionate
• Patients who are suffering from measles, chickenpox, or shingles
• Patients who are suffering from skin infection

Please consult your doctor before applying this drug to the infant. This medicine may slow down the children’s growth if used chronically. Don’t apply for the medicine if there is any sore seen on the infected area. Do consult your doctor as soon as possible. This topical medication may cause a burning sensation in the eyes. Avoid its contact with the eyes. Clobetasol Propionate doesn’t treat bruised or blistered hives having unusual colours. Talk to your dermatologist if you have these types of hives. 

Several drugs are reported to interact with the working of the drug Topinate 30 g. Some of these drugs are:

• Simvastatin
• Ritonavir
• Atorvastatin
• Cyclosporine
• Prednisone
• Pravastatin

Side Effects

The most frequent side effects reported for Topinate cream were burning and stinging sensation. Less common side effects include skin atrophy, itching, cracking, and intense dryness/thickness. Cushing syndrome has been reported in infants and adults with prolonged usage of Clobetasol propionate formulations. The additional local side effects have been reported with topical corticosteroids, and they are more likely to develop with the occlusive dressings and a higher strength corticosteroid. Other side effects associated with Clobetasol use are allergic contact dermatitis, acneiform eruptions, dryness, secondary infection, perioral dermatitis, and hypopigmentation.